STRUCTURAL BASIS FOR A DEGENERATE TRNA IDENTITY CODE AND THE EVOLUTION OF BIMODAL SPECIFICITY IN HUMAN MITOCHONDRIAL TRNA RECOGNITION

Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition

Abstract Animal mitochondrial gene expression relies on specific interactions between nuclear-encoded aminoacyl-tRNA synthetases and mitochondria-encoded tRNAs.Their evolution involves an antagonistic interplay between strong mutation pressure on mtRNAs and selection pressure to maintain their essential function.To understand the molecular conseque

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Selenium and at-risk pregnancy: challenges and controversies

Abstract Selenium (Se), an essential trace element, is inserted as selenocysteine into an array of functional proteins and forms the core of various enzymes that play a cardinal role in antioxidant defense mechanisms, in redox regulation, and in thyroid hormone metabolism.Variations in plasma Se are due to nutritional habits, geographic and ethnic

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